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AI-Edigene® ABL1 p.T315I Reference Standard Plus

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AI-Edigene® ABL1 p.T315I Reference Standard Plus

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产物编号
CBP10519
货号:
CBP10519
品牌:
Cobioer
规格:
1ug
物种:
构造:
数目
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+
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产物描写
参数
产物数据库
 CBP10519
Format Genomic DNA
Description ABL1 T315I is a gatekeeper mutation that lies within the hinge region of the protein kinase domain of the Abl1 protein (PMID: 18794843). T315I has been demonstrated to occur as a secondary resistance mutation and results in increased kinase activity and transformation in the context of BCR-ABL1 in cell culture (PMID: 11423618, PMID: 18794843, PMID: 27890928), and results in reduced catalytic efficiency (kcat/km) in an in vitro assay (PMID: 30684523), but has not been fully characterized and therefore, its effect on Abl1 protein function is unknown.
   
Technical Data 
DNA Change c.944C>T
AA Change p.T315I
Mutation type Substitution - Missense
Zygosity Homozygous
Allelic Frequency 100.00%
Transcript NM_007313.2
Buffer Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing
Storage -20°C
Expiry 36 months from the date of manufacture
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相干文件

  • COA Download:CBP10519 GBD30344262.pdf

    具体:
    2021-08-12
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